8CCW

Crystal structure of human Sirt3 in complex with an acetylated HIV1 Tat-46-54 substrate peptide

Summary for 8CCW

Entry DOI	10.2210/pdb8ccw/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Protein Tat, ZINC ION, ... (4 entities in total)
Functional Keywords	sirtuin, substrate, hiv, tat, complex, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	32629.91
Authors	Adolph, R.S.,Steegborn, C. (deposition date: 2023-01-27, release date: 2023-05-10, Last modification date: 2024-02-07)
Primary citation	Adolph, R.S.,Beck, E.,Schweimer, K.,Di Fonzo, A.,Weyand, M.,Rosch, P.,Wohrl, B.M.,Steegborn, C. Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life, 13:-, 2023 Cited by PubMed: 37109478 DOI: 10.3390/life13040949 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation