8CC4

LasB bound to phosphonic acid based inhibitor

8CC4 の概要

• エントリーDOI: 10.2210/pdb8cc4/pdb
• 分子名称: Elastase, CALCIUM ION, [(2~{R})-4-methyl-1-oxidanylidene-1-[[4-(trifluoromethyl)phenyl]amino]pentan-2-yl]phosphonic acid, ... (5 entities in total)
• 機能のキーワード: lasb, (4-methyl-1-oxo-1-((4-(trifluoromethyl)phenyl)amino)pentan-2-yl)phosphonic acid inhibitor complex, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67240.53

構造登録者

Mueller, R.,Sikandar, A. (登録日: 2023-01-26, 公開日: 2023-12-06, 最終更新日: 2024-01-10)

• 主引用文献: Konstantinovic, J.,Kany, A.M.,Alhayek, A.,Abdelsamie, A.S.,Sikandar, A.,Voos, K.,Yao, Y.,Andreas, A.,Shafiei, R.,Loretz, B.,Schonauer, E.,Bals, R.,Brandstetter, H.,Hartmann, R.W.,Ducho, C.,Lehr, C.M.,Beisswenger, C.,Muller, R.,Rox, K.,Haupenthal, J.,Hirsch, A.K.H.; Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.; Acs Cent.Sci., 9:2205-2215, 2023; PubMed: 38161367; DOI: 10.1021/acscentsci.3c01102

実験手法

X-RAY DIFFRACTION (2.7 Å)