8C89

SARS-CoV-2 spike in complex with the 17T2 neutralizing antibody Fab fragment (local refinement of RBD and Fab)

Summary for 8C89

Entry DOI	10.2210/pdb8c89/pdb
EMDB information	16473
Descriptor	Spike protein S2', 17T2 Fab heavy chain, 17T2 Fab light chain, ... (4 entities in total)
Functional Keywords	complex sars-cov-2 spike s 17t2, viral protein
Biological source	Severe acute respiratory syndrome coronavirus More
Total number of polymer chains	3
Total formula weight	72664.48
Authors	Modrego, A.,Carlero, D.,Bueno-Carrasco, M.T.,Santiago, C.,Carolis, C.,Arranz, R.,Blanco, J.,Magri, G. (deposition date: 2023-01-19, release date: 2024-01-10, Last modification date: 2024-02-21)
Primary citation	de Campos-Mata, L.,Trinite, B.,Modrego, A.,Tejedor Vaquero, S.,Pradenas, E.,Pons-Grifols, A.,Rodrigo Melero, N.,Carlero, D.,Marfil, S.,Santiago, C.,Raich-Regue, D.,Bueno-Carrasco, M.T.,Tarres-Freixas, F.,Abanco, F.,Urrea, V.,Izquierdo-Useros, N.,Riveira-Munoz, E.,Ballana, E.,Perez, M.,Vergara-Alert, J.,Segales, J.,Carolis, C.,Arranz, R.,Blanco, J.,Magri, G. A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity. Nat Commun, 15:1051-1051, 2024 Cited by PubMed: 38316751 DOI: 10.1038/s41467-024-45171-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.41 Å)

Structure validation