8C7X
Crystal structure of BRAF in complex with a hybrid compound 6
Summary for 8C7X
Entry DOI | 10.2210/pdb8c7x/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 1,2-ETHANEDIOL, BROMIDE ION, ... (5 entities in total) |
Functional Keywords | braf, kinase, kinase inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 66752.51 |
Authors | Chaikuad, A.,Bonnet, P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-01-17, release date: 2023-02-22, Last modification date: 2024-06-19) |
Primary citation | Arora, R.,Linders, J.T.M.,Aci-Seche, S.,Verheyen, T.,Van Heerde, E.,Brehmer, D.,Chaikuad, A.,Knapp, S.,Bonnet, P. Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor. Eur.J.Med.Chem., 250:115231-115231, 2023 Cited by PubMed: 36878151DOI: 10.1016/j.ejmech.2023.115231 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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