8C7V

Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format

8C7V の概要

• エントリーDOI: 10.2210/pdb8c7v/pdb
• 関連するPDBエントリー: 8C7J
• 分子名称: Fab heavy chain, Fab light chain (3 entities in total)
• 機能のキーワード: fab, immune system
• 由来する生物種: Cricetulus griseus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 141992.58

構造登録者

Adams, R.,Macpherson, A. (登録日: 2023-01-17, 公開日: 2023-06-07, 最終更新日: 2024-11-13)

主引用文献

Adams, R.,Joyce, C.,Kuravskiy, M.,Harrison, K.,Ahdash, Z.,Balmforth, M.,Chia, K.,Marceddu, C.,Coates, M.,Snowden, J.,Goursaud, E.,Menochet, K.,van den Elsen, J.,Payne, R.J.,Lawson, A.D.G.,Scott-Tucker, A.,Macpherson, A.
Serum albumin binding knob domains engineered within a V H framework III bispecific antibody format and as chimeric peptides.
Front Immunol, 14:1170357-1170357, 2023

PubMed Abstract: Serum albumin binding is an established mechanism to extend the serum half-life of antibody fragments and peptides. The cysteine rich knob domains, isolated from bovine antibody ultralong CDRH3, are the smallest single chain antibody fragments described to date and versatile tools for protein engineering.

PubMed: 37251411
DOI: 10.3389/fimmu.2023.1170357

実験手法

X-RAY DIFFRACTION (1.61 Å)