8C3J
Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22
Summary for 8C3J
Entry DOI | 10.2210/pdb8c3j/pdb |
Descriptor | DNA repair and recombination protein RadA, Breast cancer type 2 susceptibility protein, 2-[(4,6-diethyl-1,3,5-triazin-2-yl)-methyl-amino]ethanoic acid (3 entities in total) |
Functional Keywords | stapled peptide, rad51, brca2, brc repeat, recombination |
Biological source | Pyrococcus furiosus More |
Total number of polymer chains | 4 |
Total formula weight | 58682.71 |
Authors | Pantelejevs, T.,Hyvonen, M. (deposition date: 2022-12-26, release date: 2023-11-29, Last modification date: 2023-12-27) |
Primary citation | Pantelejevs, T.,Zuazua-Villar, P.,Koczy, O.,Counsell, A.J.,Walsh, S.J.,Robertson, N.S.,Spring, D.R.,Downs, J.A.,Hyvonen, M. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chem Sci, 14:13915-13923, 2023 Cited by PubMed: 38075664DOI: 10.1039/d3sc03331g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.02 Å) |
Structure validation
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