8C3J

Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22

8C3J の概要

• エントリーDOI: 10.2210/pdb8c3j/pdb
• 分子名称: DNA repair and recombination protein RadA, Breast cancer type 2 susceptibility protein, 2-[(4,6-diethyl-1,3,5-triazin-2-yl)-methyl-amino]ethanoic acid (3 entities in total)
• 機能のキーワード: stapled peptide, rad51, brca2, brc repeat, recombination
• 由来する生物種: Pyrococcus furiosus; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58682.71

構造登録者

Pantelejevs, T.,Hyvonen, M. (登録日: 2022-12-26, 公開日: 2023-11-29, 最終更新日: 2023-12-27)

• 主引用文献: Pantelejevs, T.,Zuazua-Villar, P.,Koczy, O.,Counsell, A.J.,Walsh, S.J.,Robertson, N.S.,Spring, D.R.,Downs, J.A.,Hyvonen, M.; A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.; Chem Sci, 14:13915-13923, 2023; PubMed: 38075664; DOI: 10.1039/d3sc03331g

実験手法

X-RAY DIFFRACTION (3.02 Å)