8C1H
Aurora A kinase in complex with TPX2-inhibitor 8
8C1H の概要
エントリーDOI | 10.2210/pdb8c1h/pdb |
分子名称 | Aurora kinase A, 4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ... (10 entities in total) |
機能のキーワード | protein-ligand complex, kinase, protein-protein interaction inhibitor, cell cycle |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 32650.79 |
構造登録者 | |
主引用文献 | Stockwell, S.,Scott, D.,Fischer, G.,Guarino Almeida, E.,Rooney, T.,Feng, J.,Moschetti, T.,Dagostin, C.,Alcaide-Lopez, A.,Rocaboy, M.,Srinivasan, R.,Asteian, A.,Alza, E.,Blaszczyk, B.,Wang, X.,Rossmann, M.,Perrior, T.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.,Hyvonen, M. Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.233 Å) |
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