8C19
SARS-CoV-2 NSP3 macrodomain in complex with 1-methyl-4-[5-(morpholin-4-ylcarbonyl)-2-furyl]-1H-pyrrolo[2,3-b]pyridine
Summary for 8C19
Entry DOI | 10.2210/pdb8c19/pdb |
Descriptor | Non-structural protein 3, 1,2-ETHANEDIOL, [5-(1-methylpyrrolo[2,3-b]pyridin-4-yl)furan-2-yl]-morpholin-4-yl-methanone, ... (4 entities in total) |
Functional Keywords | macrodomain, adp-ribose, sars-cov-2, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 36979.21 |
Authors | Schuller, M.,Ahel, I. (deposition date: 2022-12-20, release date: 2023-03-08, Last modification date: 2024-06-19) |
Primary citation | Schuller, M.,Zarganes-Tzitzikas, T.,Bennett, J.,De Cesco, S.,Fearon, D.,von Delft, F.,Fedorov, O.,Brennan, P.E.,Ahel, I. Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens, 12:-, 2023 Cited by PubMed: 36839595DOI: 10.3390/pathogens12020324 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report