8C0A
Crystal structure of JAK2 JH2-R683S
Summary for 8C0A
| Entry DOI | 10.2210/pdb8c0a/pdb |
| Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL, 3,5-diphenyl-2-(trifluoromethyl)-1~{H}-pyrazolo[1,5-a]pyrimidin-7-one, ... (4 entities in total) |
| Functional Keywords | janus kinase, pseudokinase, jak2, jh2, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 66996.51 |
| Authors | Haikarainen, T.,Silvennoinen, O. (deposition date: 2022-12-16, release date: 2023-12-27, Last modification date: 2024-03-20) |
| Primary citation | Abraham, B.G.,Haikarainen, T.,Vuorio, J.,Girych, M.,Virtanen, A.T.,Kurttila, A.,Karathanasis, C.,Heilemann, M.,Sharma, V.,Vattulainen, I.,Silvennoinen, O. Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling. Sci Adv, 10:eadl2097-eadl2097, 2024 Cited by PubMed: 38457493DOI: 10.1126/sciadv.adl2097 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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