8BYG
fragment-linked stabilizer for ERa - 14-3-3 interaction (1047648)
Summary for 8BYG
Entry DOI | 10.2210/pdb8byg/pdb |
Descriptor | 14-3-3 protein sigma, ERalpha peptide, ~{N}-[2-[(2-carbamimidoyl-1-benzothiophen-4-yl)-methyl-amino]ethyl]-2-(4-chloranylphenoxy)-~{N},2-dimethyl-propanamide, ... (4 entities in total) |
Functional Keywords | 14-3-3, era, fragment linking, stabilization, structural protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 27615.51 |
Authors | Visser, E.J.,Sijbesma, E.,Ottmann, C. (deposition date: 2022-12-12, release date: 2023-08-30, Last modification date: 2023-11-01) |
Primary citation | Visser, E.J.,Jaishankar, P.,Sijbesma, E.,Pennings, M.A.M.,Vandenboorn, E.M.F.,Guillory, X.,Neitz, R.J.,Morrow, J.,Dutta, S.,Renslo, A.R.,Brunsveld, L.,Arkin, M.R.,Ottmann, C. From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62:e202308004-e202308004, 2023 Cited by PubMed: 37455289DOI: 10.1002/anie.202308004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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