8BXC

Crystal structure of JAK2 JH1 in complex with itacitinib

Summary for 8BXC

• Entry DOI: 10.2210/pdb8bxc/pdb
• Descriptor: Tyrosine-protein kinase JAK2, Itacitinib, MALONATE ION, ... (4 entities in total)
• Functional Keywords: janus kinase, inhibitor complex, jak2, jh1, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 75745.64

Authors

Haikarainen, T. (deposition date: 2022-12-08, release date: 2023-12-20)

• Primary citation: Miao, Y.,Silvennoinen, O.,Haikarainen, T.; Structural basis for JAK2 inhibition by clinical stage inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)