8BX4

fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392)

8BX4 の概要

• エントリーDOI: 10.2210/pdb8bx4/pdb
• 分子名称: 14-3-3 protein sigma, ERalpha peptide, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ... (4 entities in total)
• 機能のキーワード: 14-3-3, era, fragment linking, stabilization, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27604.88

構造登録者

Visser, E.J.,Vandenboorn, E.M.F.,Ottmann, C. (登録日: 2022-12-07, 公開日: 2023-08-02, 最終更新日: 2023-09-13)

• 主引用文献: Visser, E.J.,Jaishankar, P.,Sijbesma, E.,Pennings, M.A.M.,Vandenboorn, E.M.F.,Guillory, X.,Neitz, R.J.,Morrow, J.,Dutta, S.,Renslo, A.R.,Brunsveld, L.,Arkin, M.R.,Ottmann, C.; From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.; Angew.Chem.Int.Ed.Engl., 62:e202308004-e202308004, 2023; PubMed: 37455289; DOI: 10.1002/anie.202308004

実験手法

X-RAY DIFFRACTION (1.6 Å)