8BWF

PTBP1 RRM1 bound to an allosteric inhibitor

Summary for 8BWF

• Entry DOI: 10.2210/pdb8bwf/pdb
• Descriptor: Polypyrimidine tract-binding protein 1, Ligand, SULFATE ION, ... (5 entities in total)
• Functional Keywords: rna binding, protein-peptide interaction, inhibitor, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 32
• Total formula weight: 181201.37

Authors

Schmeing, S.,Vetter, I.,t Hart, P.,Gasper, R. (deposition date: 2022-12-06, release date: 2023-10-11, Last modification date: 2023-11-15)

• Primary citation: Schmeing, S.,Amrahova, G.,Bigler, K.,Chang, J.Y.,Openy, J.,Pal, S.,Posada, L.,Gasper, R.,'t Hart, P.; Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding.; Chem Sci, 14:8269-8278, 2023; PubMed: 37564416; DOI: 10.1039/d3sc00985h

Experimental method

X-RAY DIFFRACTION (2.9 Å)