8BUZ

Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP

Summary for 8BUZ

• Entry DOI: 10.2210/pdb8buz/pdb
• EMDB information: 16252
• Descriptor: Adenylate cyclase type 8, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, FORSKOLIN, ... (5 entities in total)
• Functional Keywords: adenylyl cyclase, camp signaling, g proteins, calmodulin, membrane protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 2
• Total formula weight: 188170.18

Authors

Khanppnavar, B.,Korkhov, V.M.,Mehta, V. (deposition date: 2022-12-01, release date: 2023-12-13, Last modification date: 2024-06-12)

• Primary citation: Khanppnavar, B.,Schuster, D.,Lavriha, P.,Uliana, F.,Ozel, M.,Mehta, V.,Leitner, A.,Picotti, P.,Korkhov, V.M.; Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics.; Embo Rep., 25:1513-1540, 2024; PubMed: 38351373; DOI: 10.1038/s44319-024-00076-y

Experimental method

ELECTRON MICROSCOPY (3.5 Å)