8BUF

Structure of DDB1 bound to Z12-engaged CDK12-cyclin K

8BUF の概要

• エントリーDOI: 10.2210/pdb8buf/pdb
• 分子名称: DNA damage-binding protein 1, Cyclin-dependent kinase 12, Cyclin-K, ... (5 entities in total)
• 機能のキーワード: kinase, cyclin, ubiquitin, degrader, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 502048.89

構造登録者

Kozicka, Z.,Kempf, G.,Petzold, G.,Thoma, N.H. (登録日: 2022-11-30, 公開日: 2023-09-13, 最終更新日: 2024-01-03)

• 主引用文献: Kozicka, Z.,Suchyta, D.J.,Focht, V.,Kempf, G.,Petzold, G.,Jentzsch, M.,Zou, C.,Di Genua, C.,Donovan, K.A.,Coomar, S.,Cigler, M.,Mayor-Ruiz, C.,Schmid-Burgk, J.L.,Haussinger, D.,Winter, G.E.,Fischer, E.S.,Slabicki, M.,Gillingham, D.,Ebert, B.L.,Thoma, N.H.; Design principles for cyclin K molecular glue degraders.; Nat.Chem.Biol., 20:93-102, 2024; PubMed: 37679459; DOI: 10.1038/s41589-023-01409-z

実験手法

X-RAY DIFFRACTION (3.3 Å)