8BTP
Helical structure of BcThsA in complex with 1''-3'gc(etheno)ADPR
Summary for 8BTP
Entry DOI | 10.2210/pdb8btp/pdb |
Related | 8BTN 8BTO |
EMDB information | 16233 16234 |
Descriptor | NAD(+) hydrolase ThsA, (1S,3S,4R,5R,7R,15R,16S,17R)-5-imidazo[2,1-f]purin-3-yl-10,12-bis(oxidanyl)-10,12-bis(oxidanylidene)-2,6,9,11,13,18-hexaoxa-10$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{3,7}]octadecane-4,16,17-triol, ETHENO-NAD (3 entities in total) |
Functional Keywords | thoeris, sir2 domain, slog domain, 3'cadpr, hydrolase |
Biological source | Bacillus cereus MSX-D12 |
Total number of polymer chains | 12 |
Total formula weight | 680046.18 |
Authors | Tamulaitiene, G.,Sasnauskas, G.,Sabonis, D. (deposition date: 2022-11-29, release date: 2024-02-21, Last modification date: 2024-04-03) |
Primary citation | Tamulaitiene, G.,Sabonis, D.,Sasnauskas, G.,Ruksenaite, A.,Silanskas, A.,Avraham, C.,Ofir, G.,Sorek, R.,Zaremba, M.,Siksnys, V. Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature, 627:431-436, 2024 Cited by PubMed: 38383786DOI: 10.1038/s41586-024-07092-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.75 Å) |
Structure validation
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