8BSG

COMPLEX OF LEPORINE SERUM ALBUMIN WITH DICLOFENAC

8BSG の概要

• エントリーDOI: 10.2210/pdb8bsg/pdb
• 分子名称: Albumin, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ACETATE ION, ... (7 entities in total)
• 機能のキーワード: leporine serum albumin, drug carrier, diclofenac., transport protein
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 68144.44

構造登録者

Bujacz, A.,Talaj, J.,Zielinski, K. (登録日: 2022-11-25, 公開日: 2023-02-08, 最終更新日: 2024-10-09)

主引用文献

Talaj, J.A.,Zielinski, K.,Bujacz, A.
Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
Int J Mol Sci, 24:-, 2023

PubMed Abstract: Free drug concentration in the blood sera is crucial for its appropriate activity. Serum albumin, the universal blood carrier protein, is responsible for transporting drugs and releasing them into the bloodstream. Therefore, a drug's binding to SA is especially important for its bioavailability and it is a key problem in the drug design process. In this paper, we present crystal structures of three animal serum albumin complexes: ovine, caprine, and leporine, with diclofenac, a popular non-steroidal anti-inflammatory drug that is used in therapy of chronic and acute pain. Details of diclofenac binding mode by the presented serum albumins are compared with analogous complexes of human and equine serum albumins. The analysis of the occupied binding pockets in crystal structures of the investigated serum albumins from different mammals shows that they have two common and a number of unique diclofenac binding sites. The most intriguing is the fact that the albumins from the described species are able to bind different numbers of molecules of this popular anti-inflammatory drug, but none of the binding sites overlap with ones in the human serum albumin.

PubMed: 36675044
DOI: 10.3390/ijms24021534

実験手法

X-RAY DIFFRACTION (1.89 Å)