8BPE

8:1 binding of FcMR on IgM pentameric core

8BPE の概要

• エントリーDOI: 10.2210/pdb8bpe/pdb
• EMDBエントリー: 16150
• 分子名称: Immunoglobulin heavy constant mu, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... (5 entities in total)
• 機能のキーワード: igm fc receptor, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 19
• 化学式量合計: 612759.25

構造登録者

Chen, Q.,Rosenthal, P.,Tolar, P. (登録日: 2022-11-16, 公開日: 2023-04-12, 最終更新日: 2024-10-23)

主引用文献

Chen, Q.,Menon, R.P.,Masino, L.,Tolar, P.,Rosenthal, P.B.
Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30:1033-1039, 2023

PubMed Abstract: Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of antibody production. FcμR is the immunoglobulin M (IgM) antibody isotype-specific Fc receptor involved in the survival and activation of B cells. Here we reveal eight binding sites for the human FcμR immunoglobulin domain on the IgM pentamer by cryogenic electron microscopy. One of the sites overlaps with the binding site for the polymeric immunoglobulin receptor (pIgR), but a different mode of FcμR binding explains its antibody isotype specificity. Variation in FcμR binding sites and their occupancy reflects the asymmetry of the IgM pentameric core and the versatility of FcμR binding. The complex explains engagement with polymeric serum IgM and the monomeric IgM B-cell receptor (BCR).

PubMed: 37095205
DOI: 10.1038/s41594-023-00985-x

実験手法

ELECTRON MICROSCOPY (3.63 Å)