8BP1

Crystal structure of BHMeHis1.0, an engineered enzyme for the Morita-Baylis-Hillman reaction

8BP1 の概要

• エントリーDOI: 10.2210/pdb8bp1/pdb
• 分子名称: BHMeHis1.0, DI(HYDROXYETHYL)ETHER, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: morita-baylis-hillman, non-canonical amino acid, methylhistidine, de novo enzyme, biosynthetic protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28005.64

構造登録者

Hardy, F.J. (登録日: 2022-11-15, 公開日: 2024-02-28, 最終更新日: 2024-03-13)

• 主引用文献: Hutton, A.E.,Foster, J.,Crawshaw, R.,Hardy, F.J.,Johannissen, L.O.,Lister, T.M.,Gerard, E.F.,Birch-Price, Z.,Obexer, R.,Hay, S.,Green, A.P.; A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme.; Nat Commun, 15:1956-1956, 2024; PubMed: 38438341; DOI: 10.1038/s41467-024-46123-z

実験手法

X-RAY DIFFRACTION (1.72 Å)