8BOP

LSD1-CoREST in complex with AW4, long soaking

8BOP の概要

• エントリーDOI: 10.2210/pdb8bop/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[7,8-dimethyl-2,4-bis(oxidanylidene)-5-[3-[4-(3-phenylphenyl)phenyl]propanoyl]-1~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate (3 entities in total)
• 機能のキーワード: demethylase, histone, splicing, epigenetics, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112583.29

構造登録者

Caroli, J.,Mattevi, A. (登録日: 2022-11-15, 公開日: 2024-06-05)

• 主引用文献: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; to be published,

実験手法

X-RAY DIFFRACTION (2.74 Å)