8BOI

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 9

Summary for 8BOI

Entry DOI	10.2210/pdb8boi/pdb
Descriptor	Ephrin type-A receptor 2, 4-methyl-~{N}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide (3 entities in total)
Functional Keywords	inhibitor, complex, protein tyrosine kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35078.49
Authors	Linhard, V.,Witt, K.,Gande, S.,Wollenhaupt, J.,Lennartz, F.,Weiss, M.S.,Schwalbe, H. (deposition date: 2022-11-15, release date: 2023-03-08, Last modification date: 2024-02-07)
Primary citation	Troster, A.,DiPrima, M.,Jores, N.,Kudlinzki, D.,Sreeramulu, S.,Gande, S.L.,Linhard, V.,Ludig, D.,Schug, A.,Saxena, K.,Reinecke, M.,Heinzlmeir, S.,Leisegang, M.S.,Wollenhaupt, J.,Lennartz, F.,Weiss, M.S.,Kuster, B.,Tosato, G.,Schwalbe, H. Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor. Chemistry, 29:e202203967-e202203967, 2023 Cited by PubMed: 36799129 DOI: 10.1002/chem.202203967 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation