8BOD

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 20

8BOD の概要

• エントリーDOI: 10.2210/pdb8bod/pdb
• 分子名称: Ephrin type-A receptor 2, ~{N}-[3,5-bis(chloranyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide (3 entities in total)
• 機能のキーワード: inhibitor, complex, protein tyropsine kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34967.21

構造登録者

Linhard, V.,Witt, K.,Gande, S.,Wollenhaupt, J.,Lennartz, F.,Weiss, M.S.,Schwalbe, H. (登録日: 2022-11-15, 公開日: 2023-03-08, 最終更新日: 2024-02-07)

• 主引用文献: Troster, A.,DiPrima, M.,Jores, N.,Kudlinzki, D.,Sreeramulu, S.,Gande, S.L.,Linhard, V.,Ludig, D.,Schug, A.,Saxena, K.,Reinecke, M.,Heinzlmeir, S.,Leisegang, M.S.,Wollenhaupt, J.,Lennartz, F.,Weiss, M.S.,Kuster, B.,Tosato, G.,Schwalbe, H.; Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.; Chemistry, 29:e202203967-e202203967, 2023; PubMed: 36799129; DOI: 10.1002/chem.202203967

実験手法

X-RAY DIFFRACTION (1.5 Å)