8BN1
The structures of Ace2 in complex with bicyclic peptide inhibitor
Summary for 8BN1
| Entry DOI | 10.2210/pdb8bn1/pdb |
| Descriptor | Processed angiotensin-converting enzyme 2, ALA-CYS-VAL-ARG-SER-4PH-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, ZINC ION, ... (5 entities in total) |
| Functional Keywords | cov-2-sars bind proteins, membrane protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 146111.20 |
| Authors | Brear, P.,Lulla, A.,Harman, M.,Dods, R.,Chen, L.,Bezerra, G.,Demydchuk, Y.,Stanway, S.,Hyvonen, M. (deposition date: 2022-11-11, release date: 2023-09-20) |
| Primary citation | Harman, M.A.J.,Stanway, S.J.,Scott, H.,Demydchuk, Y.,Bezerra, G.A.,Pellegrino, S.,Chen, L.,Brear, P.,Lulla, A.,Hyvonen, M.,Beswick, P.J.,Skynner, M.J. Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2. J.Med.Chem., 66:9881-9893, 2023 Cited by PubMed: 37433017DOI: 10.1021/acs.jmedchem.3c00710 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report
