8BL1
Human Sirt6 in complex with the inhibitor S6039 and ADP-ribose
Summary for 8BL1
Entry DOI | 10.2210/pdb8bl1/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total) |
Functional Keywords | deacylase, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70620.99 |
Authors | |
Primary citation | You, W.,Steegborn, C. Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
Download full validation report