8BL0

Human Sirt6 in complex with the inhibitor S6023 and ADP-ribose

8BL0 の概要

• エントリーDOI: 10.2210/pdb8bl0/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total)
• 機能のキーワード: deacylase, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70616.36

構造登録者

You, W.,Steegborn, C. (登録日: 2022-11-09, 公開日: 2023-11-22)

• 主引用文献: You, W.,Steegborn, C.; Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen; To Be Published,

実験手法

X-RAY DIFFRACTION (1.82 Å)