8BIN

Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21

Summary for 8BIN

Entry DOI	10.2210/pdb8bin/pdb
Descriptor	Ephrin type-A receptor 2, 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, ... (4 entities in total)
Functional Keywords	epha2, eck, typ i inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35255.15
Authors	Zhubi, R.,Rak, M.,Knapp, S.,Kraemer, A.,Structural Genomics Consortium (SGC) (deposition date: 2022-11-02, release date: 2022-11-23, Last modification date: 2024-07-31)
Primary citation	Gerninghaus, J.,Zhubi, R.,Kramer, A.,Karim, M.,Tran, D.H.N.,Joerger, A.C.,Schreiber, C.,Berger, L.M.,Berger, B.T.,Ehret, T.A.L.,Elson, L.,Lenz, C.,Saxena, K.,Muller, S.,Einav, S.,Knapp, S.,Hanke, T. Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. J.Med.Chem., 2024 Cited by PubMed: 39028937 DOI: 10.1021/acs.jmedchem.4c00411 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation