8BIN

Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21

Summary for 8BIN

Entry DOI	10.2210/pdb8bin/pdb
Descriptor	Ephrin type-A receptor 2, 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, ... (4 entities in total)
Functional Keywords	epha2, eck, typ i inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35255.15
Authors	Zhubi, R.,Rak, M.,Knapp, S.,Kraemer, A.,Structural Genomics Consortium (SGC) (deposition date: 2022-11-02, release date: 2022-11-23, Last modification date: 2024-01-31)
Primary citation	Rak, M.,Tesch, R.,Berger, L.M.,Shevchenko, E.,Raab, M.,Tjaden, A.,Zhubi, R.,Balourdas, D.I.,Joerger, A.C.,Poso, A.,Kramer, A.,Elson, L.,Lucic, A.,Kronenberger, T.,Hanke, T.,Strebhardt, K.,Sanhaji, M.,Knapp, S. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254:115347-115347, 2023 Cited by PubMed: 37094449 DOI: 10.1016/j.ejmech.2023.115347 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation