8BI8
Structure of a cyclic beta-hairpin peptide derived from neuronal nitric oxide synthase
Summary for 8BI8
| Entry DOI | 10.2210/pdb8bi8/pdb |
| Descriptor | Nitric oxide synthase, brain (2 entities in total) |
| Functional Keywords | cyclic beta-hairpin, neuronal nitric oxidase synthase, inhibitor of the nos/psd-95 interaction, peptide drugs, stroke treatment, protein binding |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 4977.45 |
| Authors | Balboa, J.R.,Ostergaard, S.,Stromgaard, K.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2022-11-01, release date: 2022-12-21, Last modification date: 2024-02-07) |
| Primary citation | Balboa, J.R.,Essig, D.J.,Ma, S.,Karer, N.,Clemmensen, L.S.,Pedersen, S.W.,Joerger, A.C.,Knapp, S.,Ostergaard, S.,Stromgaard, K. Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. J.Med.Chem., 66:976-990, 2023 Cited by PubMed: 36580549DOI: 10.1021/acs.jmedchem.2c01803 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
Download full validation report
