8BAJ

Structure of the FK1 domain of the FKBP51 G64S variant in complex with (1S,5S,6R)-10-((3,5-dichlorophenyl)sulfonyl)-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one

Summary for 8BAJ

Entry DOI	10.2210/pdb8baj/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one (3 entities in total)
Functional Keywords	isomerase inhibitor complex, isomerase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	14518.45
Authors	Meyners, C.,Hausch, F. (deposition date: 2022-10-11, release date: 2022-11-16, Last modification date: 2024-01-31)
Primary citation	Lerma Romero, J.A.,Meyners, C.,Christmann, A.,Reinbold, L.M.,Charalampidou, A.,Hausch, F.,Kolmar, H. Binding pocket stabilization by high-throughput screening of yeast display libraries. Front Mol Biosci, 9:1023131-1023131, 2022 Cited by PubMed: 36419931 DOI: 10.3389/fmolb.2022.1023131 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation