8BAJ

Structure of the FK1 domain of the FKBP51 G64S variant in complex with (1S,5S,6R)-10-((3,5-dichlorophenyl)sulfonyl)-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one

8BAJ の概要

• エントリーDOI: 10.2210/pdb8baj/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one (3 entities in total)
• 機能のキーワード: isomerase inhibitor complex, isomerase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14518.45

構造登録者

Meyners, C.,Hausch, F. (登録日: 2022-10-11, 公開日: 2022-11-16, 最終更新日: 2024-01-31)

• 主引用文献: Lerma Romero, J.A.,Meyners, C.,Christmann, A.,Reinbold, L.M.,Charalampidou, A.,Hausch, F.,Kolmar, H.; Binding pocket stabilization by high-throughput screening of yeast display libraries.; Front Mol Biosci, 9:1023131-1023131, 2022; PubMed: 36419931; DOI: 10.3389/fmolb.2022.1023131

実験手法

X-RAY DIFFRACTION (1.2 Å)