8BAB
Crystal structure of JAK2 JH2-V617F in complex with CB76
Summary for 8BAB
| Entry DOI | 10.2210/pdb8bab/pdb |
| Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL, 6-[(1-methylimidazol-2-yl)sulfanylmethyl]-~{N}4-(3-methylphenyl)-1,3,5-triazine-2,4-diamine, ... (4 entities in total) |
| Functional Keywords | janus kinase, pseudokinase, inhibitor complex, jak2, jh2, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34256.20 |
| Authors | Haikarainen, T.,Silvennoinen, O. (deposition date: 2022-10-11, release date: 2023-02-01, Last modification date: 2024-02-07) |
| Primary citation | Virtanen, A.T.,Haikarainen, T.,Sampathkumar, P.,Palmroth, M.,Liukkonen, S.,Liu, J.,Nekhotiaeva, N.,Hubbard, S.R.,Silvennoinen, O. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 36678572DOI: 10.3390/ph16010075 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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