8B9R

Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease

8B9R の概要

• エントリーDOI: 10.2210/pdb8b9r/pdb
• NMR情報: BMRB: 34763
• 分子名称: Amyloid-beta A4 protein, COPPER (II) ION (2 entities in total)
• 機能のキーワード: amyloid-beta peptide, alzheimer's disease, copper ion, paramagnetic nmr, aggregation kinetics, metal binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4399.40

構造登録者

Abelein, A.,Ciofi-Baffoni, S.,Morman, C.,Kumar, R.,Giachetti, A.,Piccioli, M.,Biverstal, H. (登録日: 2022-10-06, 公開日: 2023-02-01, 最終更新日: 2024-06-19)

• 主引用文献: Abelein, A.,Ciofi-Baffoni, S.,Morman, C.,Kumar, R.,Giachetti, A.,Piccioli, M.,Biverstal, H.; Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.; Jacs Au, 2:2571-2584, 2022; PubMed: 36465548; DOI: 10.1021/jacsau.2c00438

実験手法

SOLUTION NMR