8B98

Crystal structure of the human BRD4-BD1 bromodomain in complex with the inhibitor CRCM5483

8B98 の概要

• エントリーDOI: 10.2210/pdb8b98/pdb
• 分子名称: Bromodomain-containing protein 4, ~{N}-[[4-[[7-ethyl-2,6-bis(oxidanylidene)purin-3-yl]methyl]cyclohexyl]methyl]-3-fluoranyl-4-(oxan-4-yloxy)benzenesulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: epigenetic, inhibition, inhibitor, selectivity, complex, bd1, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15927.36

構造登録者

Carrasco, K.,Betzi, S.,Morelli, X. (登録日: 2022-10-05, 公開日: 2024-04-03)

• 主引用文献: Carrasco, K.,Betzi, S.,Morelli, X.; Crystal structure of the human BRD4-BD1 bromodomain in complex with the inhibitor CRCM5464; To Be Published,

実験手法

X-RAY DIFFRACTION (1.495 Å)