8B8W

Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 7a)

8B8W の概要

• エントリーDOI: 10.2210/pdb8b8w/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 2, 4-chloranyl-~{N}3-phenyl-~{N}1-(phenylmethyl)benzene-1,3-dicarboxamide, ... (5 entities in total)
• 機能のキーワード: nuclear hormone receptor transcription factor, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69823.88

構造登録者

Friberg, A.,Orsi, D.L.,Pook, E.,Siegel, S.,Lemke, C.T.,Stellfeld, T.,Puetter, V.,Goldstein, J. (登録日: 2022-10-05, 公開日: 2022-12-28, 最終更新日: 2024-05-01)

• 主引用文献: Orsi, D.L.,Ferrara, S.J.,Siegel, S.,Friberg, A.,Bouche, L.,Pook, E.,Lienau, P.,Bluck, J.P.,Lemke, C.T.,Akcay, G.,Stellfeld, T.,Meyer, H.,Putter, V.,Holton, S.J.,Korr, D.,Jerchel-Furau, I.,Pantelidou, C.,Strathdee, C.A.,Meyerson, M.,Eis, K.,Goldstein, J.T.; Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.; Bioorg.Med.Chem., 78:117130-117130, 2022; PubMed: 36542958; DOI: 10.1016/j.bmc.2022.117130

実験手法

X-RAY DIFFRACTION (1.86 Å)