8B8H

Structure of DCS-resistant variant D322N of alanine racemase from M. tuberculosis in complex with DCS

8B8H の概要

• エントリーDOI: 10.2210/pdb8b8h/pdb
• 関連するPDBエントリー: 8AHW
• 分子名称: Alanine racemase, [2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl-(3-oxidanyl-1,2-oxazol-4-yl)azanium, (~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylidene-[(4~{R})-3-oxidanylidene-1,2-oxazolidin-4-yl]azanium, ... (8 entities in total)
• 機能のキーワード: enzyme, alanine racemase, peptidoglycan biosynthesis, isomerase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83485.74

構造登録者

de Chiara, C.,Prosser, G.,Ogrodowicz, R.W.,de Carvalho, L.P.S. (登録日: 2022-10-04, 公開日: 2023-04-05, 最終更新日: 2024-02-07)

• 主引用文献: de Chiara, C.,Prosser, G.A.,Ogrodowicz, R.,de Carvalho, L.P.S.; Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis .; Acs Bio Med Chem Au, 3:233-239, 2023; PubMed: 37363078; DOI: 10.1021/acsbiomedchemau.2c00074

実験手法

X-RAY DIFFRACTION (1.78 Å)