8B5A

Human BRD3 bromodomain 2 in complex with a H4 peptide containing ApmTri (H4K20ApmTri)

8B5A の概要

• エントリーDOI: 10.2210/pdb8b5a/pdb
• 分子名称: Bromodomain-containing protein 3, H4K20ApmTri (3 entities in total)
• 機能のキーワード: apmtri, acetyl-lysine mimic, bet-bromodomain, histone-peptide, peptide binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14301.51

構造登録者

Braun, M.B.,Bartlick, N.,Stehle, T. (登録日: 2022-09-22, 公開日: 2023-01-11, 最終更新日: 2024-02-07)

• 主引用文献: Kirchgassner, S.,Braun, M.B.,Bartlick, N.,Koc, C.,Reinkemeier, C.D.,Lemke, E.A.,Stehle, T.,Schwarzer, D.; Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family.; Angew.Chem.Int.Ed.Engl., 62:e202215460-e202215460, 2023; PubMed: 36585954; DOI: 10.1002/anie.202215460

実験手法

X-RAY DIFFRACTION (1.92 Å)