8B3J
Chaetoceros socialis forma radians RNA virus 1 empty capsid atomic model
8B3J の概要
エントリーDOI | 10.2210/pdb8b3j/pdb |
EMDBエントリー | 15830 |
分子名称 | Structural polyprotein (3 entities in total) |
機能のキーワード | icosahedral, empty particle capsid, virus |
由来する生物種 | Chaetoceros socialis forma radians RNA virus 1 詳細 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 87900.58 |
構造登録者 | |
主引用文献 | Wang, H.,Munke, A.,Li, S.,Tomaru, Y.,Okamoto, K. Structural Insights into Common and Host-Specific Receptor-Binding Mechanisms in Algal Picorna-like Viruses. Viruses, 14:-, 2022 Cited by PubMed Abstract: viruses are abundant algal viruses that regulate the dynamics of algal blooms in aquatic environments. They employ a narrow host range because they merely lyse their algal host species. This host-specific lysis is thought to correspond to the unique receptor-binding mechanism of the viruses. Here, we present the atomic structures of the full and empty capsids of Chaetoceros socialis forma radians RNA virus 1 built-in 3.0 Å and 3.1 Å cryo-electron microscopy maps. The empty capsid structure and the structural variability provide insights into its assembly and uncoating intermediates. In conjunction with the previously reported atomic model of the Chaetoceros tenuissimus RNA virus type II capsid, we have identified the common and diverse structural features of the VP1 surface between the viruses. We have also tested the potential usage of AlphaFold2 for structural prediction of the VP1s and a subsequent structural phylogeny for classifying viruses by their hosts. These findings will be crucial for inferring the host-specific receptor-binding mechanism in viruses. PubMed: 36366467DOI: 10.3390/v14112369 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (3.1 Å) |
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