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8B3J

Chaetoceros socialis forma radians RNA virus 1 empty capsid atomic model

8B3J の概要
エントリーDOI10.2210/pdb8b3j/pdb
EMDBエントリー15830
分子名称Structural polyprotein (3 entities in total)
機能のキーワードicosahedral, empty particle capsid, virus
由来する生物種Chaetoceros socialis forma radians RNA virus 1
詳細
タンパク質・核酸の鎖数3
化学式量合計87900.58
構造登録者
Wang, H.,Okamoto, K.,Munke, A. (登録日: 2022-09-16, 公開日: 2022-11-23, 最終更新日: 2024-07-24)
主引用文献Wang, H.,Munke, A.,Li, S.,Tomaru, Y.,Okamoto, K.
Structural Insights into Common and Host-Specific Receptor-Binding Mechanisms in Algal Picorna-like Viruses.
Viruses, 14:-, 2022
Cited by
PubMed Abstract: viruses are abundant algal viruses that regulate the dynamics of algal blooms in aquatic environments. They employ a narrow host range because they merely lyse their algal host species. This host-specific lysis is thought to correspond to the unique receptor-binding mechanism of the viruses. Here, we present the atomic structures of the full and empty capsids of Chaetoceros socialis forma radians RNA virus 1 built-in 3.0 Å and 3.1 Å cryo-electron microscopy maps. The empty capsid structure and the structural variability provide insights into its assembly and uncoating intermediates. In conjunction with the previously reported atomic model of the Chaetoceros tenuissimus RNA virus type II capsid, we have identified the common and diverse structural features of the VP1 surface between the viruses. We have also tested the potential usage of AlphaFold2 for structural prediction of the VP1s and a subsequent structural phylogeny for classifying viruses by their hosts. These findings will be crucial for inferring the host-specific receptor-binding mechanism in viruses.
PubMed: 36366467
DOI: 10.3390/v14112369
主引用文献が同じPDBエントリー
実験手法
ELECTRON MICROSCOPY (3.1 Å)
構造検証レポート
Validation report summary of 8b3j
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-11-06に公開中

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