8B3A

catalytic amyloid fibril formed by Ac-LHLHLRL-amide

8B3A の概要

• エントリーDOI: 10.2210/pdb8b3a/pdb
• EMDBエントリー: 15824
• 分子名称: ACE-LEU-HIS-LEU-HIS-LEU-ARG-LEU-NH2 (1 entity in total)
• 機能のキーワード: catalytic amyloid fibril, protein fibril, zinc binding, prion
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 30
• 化学式量合計: 27845.37

構造登録者

Heerde, T.,Schmidt, M.,Faendrich, M. (登録日: 2022-09-16, 公開日: 2023-04-05, 最終更新日: 2024-11-20)

主引用文献

Heerde, T.,Bansal, A.,Schmidt, M.,Fandrich, M.
Cryo-EM structure of a catalytic amyloid fibril.
Sci Rep, 13:4070-4070, 2023

PubMed Abstract: Catalytic amyloid fibrils are novel types of bioinspired, functional materials that combine the chemical and mechanical robustness of amyloids with the ability to catalyze a certain chemical reaction. In this study we used cryo-electron microcopy to analyze the amyloid fibril structure and the catalytic center of amyloid fibrils that hydrolyze ester bonds. Our findings show that catalytic amyloid fibrils are polymorphic and consist of similarly structured, zipper-like building blocks that consist of mated cross-β sheets. These building blocks define the fibril core, which is decorated by a peripheral leaflet of peptide molecules. The observed structural arrangement differs from previously described catalytic amyloid fibrils and yielded a new model of the catalytic center.

PubMed: 36906667
DOI: 10.1038/s41598-023-30711-y

実験手法

ELECTRON MICROSCOPY (3.8 Å)