8AXW

The structure of mouse AsterC (GramD1c) with Ezetimibe

Summary for 8AXW

Entry DOI	10.2210/pdb8axw/pdb
Descriptor	Protein Aster-C, GLYCEROL, ETHANOL, ... (7 entities in total)
Functional Keywords	cholesterol, plasma membrane, endoplasmic reticulum, lipid transport
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	27176.09
Authors	Fairall, L.,Xiao, X.,Burger, L.,Tontonoz, P.,Schwabe, J.W.R. (deposition date: 2022-09-01, release date: 2023-09-13, Last modification date: 2024-03-20)
Primary citation	Ferrari, A.,Whang, E.,Xiao, X.,Kennelly, J.P.,Romartinez-Alonso, B.,Mack, J.J.,Weston, T.,Chen, K.,Kim, Y.,Tol, M.J.,Bideyan, L.,Nguyen, A.,Gao, Y.,Cui, L.,Bedard, A.H.,Sandhu, J.,Lee, S.D.,Fairall, L.,Williams, K.J.,Song, W.,Munguia, P.,Russell, R.A.,Martin, M.G.,Jung, M.E.,Jiang, H.,Schwabe, J.W.R.,Young, S.G.,Tontonoz, P. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science, 382:eadf0966-eadf0966, 2023 Cited by PubMed: 37943936 DOI: 10.1126/science.adf0966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation