8AX7

Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor HTL0031448

8AX7 の概要

• エントリーDOI: 10.2210/pdb8ax7/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, TETRAETHYLENE GLYCOL, ... (6 entities in total)
• 機能のキーワード: cgrp, cgrpr, ectodomain, ramp, macrocycle, macrocyclic, membrane protein
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67636.87

構造登録者

Southall, S.M.,Watson, S.P. (登録日: 2022-08-30, 公開日: 2022-12-07, 最終更新日: 2024-01-31)

• 主引用文献: Southall, S.M.,Banerjee, J.,Brown, J.,Butkovic, K.,Cansfield, A.D.,Cansfield, J.E.,Congreve, M.S.,Cseke, G.,Deflorian, F.,Hunjadi, M.P.,Hutinec, A.,Inturi, T.K.,Rupcic, R.,Saxty, G.,Watson, S.P.; Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.; Acs Med.Chem.Lett., 13:1776-1782, 2022; PubMed: 36385934; DOI: 10.1021/acsmedchemlett.2c00400

実験手法

X-RAY DIFFRACTION (1.65 Å)