8ATZ

Crystal structure of PPAR gamma (PPARG) in complex with SA112 (compound 2).

Summary for 8ATZ

Entry DOI	10.2210/pdb8atz/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, GLYCEROL, 2-[4-chloranyl-6-[[3-(2-phenylethoxy)phenyl]amino]pyrimidin-2-yl]sulfanylethanoic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, pparg, inhibitor, structural genomics, structural genomics consortium, sgc, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32175.78
Authors	Chaikuad, A.,Arifi, S.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-08-24, release date: 2023-07-12, Last modification date: 2024-02-07)
Primary citation	Arifi, S.,Marschner, J.A.,Pollinger, J.,Isigkeit, L.,Heitel, P.,Kaiser, A.,Obeser, L.,Hofner, G.,Proschak, E.,Knapp, S.,Chaikuad, A.,Heering, J.,Merk, D. Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145:14802-14810, 2023 Cited by PubMed: 37385602 DOI: 10.1021/jacs.3c03417 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation