Summary for 8ATL
Entry DOI | 10.2210/pdb8atl/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, ~{N}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{R})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide, ... (4 entities in total) |
Functional Keywords | irak4, kinase, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 67576.04 |
Authors | Schafer, M.,Bothe, U.,Schmidt, N.,Gunther, J.,Nubbemeyer, R.,Siebeneicher, H.,Ring, S.,Boemer, U.,Peters, M.,Denner, K.,Himmel, H.,Sutter, A.,Terebesi, I.,Lange, M.,Wenger, A.M.,Guimond, N.,Thaler, T.,Platzek, J.,Eberspaecher, U.,Steuber, H.,Steinmeyer, A.,Zollner, T.M. (deposition date: 2022-08-23, release date: 2023-09-06, Last modification date: 2024-02-07) |
Primary citation | Bothe, U.,Gunther, J.,Nubbemeyer, R.,Siebeneicher, H.,Ring, S.,Bomer, U.,Peters, M.,Rausch, A.,Denner, K.,Himmel, H.,Sutter, A.,Terebesi, I.,Lange, M.,Wengner, A.M.,Guimond, N.,Thaler, T.,Platzek, J.,Eberspacher, U.,Schafer, M.,Steuber, H.,Zollner, T.M.,Steinmeyer, A.,Schmidt, N. Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 . J.Med.Chem., 67:1225-1242, 2024 Cited by PubMed: 38228402DOI: 10.1021/acs.jmedchem.3c01714 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.464 Å) |
Structure validation
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