8AQW

BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)

8AQW の概要

• エントリーDOI: 10.2210/pdb8aqw/pdb
• EMDBエントリー: 15592
• 分子名称: Spike glycoprotein,Fibritin, Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, A allele, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: sars-cov2, omicron, spike, rbd, mouse, ace2, antiviral protein, ba4/5, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 244522.97

構造登録者

Lau, K.,Ni, D.,Beckert, B.,Nazarov, S.,Myasnikov, A.,Pojer, F.,Stahlberg, H.,Uchikawa, E. (登録日: 2022-08-13, 公開日: 2023-03-15, 最終更新日: 2023-04-19)

• 主引用文献: Ni, D.,Turelli, P.,Beckert, B.,Nazarov, S.,Uchikawa, E.,Myasnikov, A.,Pojer, F.,Trono, D.,Stahlberg, H.,Lau, K.; Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.; Plos Pathog., 19:e1011206-e1011206, 2023; PubMed: 37018380; DOI: 10.1371/journal.ppat.1011206

実験手法

ELECTRON MICROSCOPY (3.3 Å)