8AQB

Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2257

8AQB の概要

• エントリーDOI: 10.2210/pdb8aqb/pdb
• 分子名称: Serine protease subunit NS2B, Serine protease NS3, (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, ... (5 entities in total)
• 機能のキーワード: flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
• 由来する生物種: Zika virus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 25669.86

構造登録者

Huber, S.,Steinmetzer, T. (登録日: 2022-08-11, 公開日: 2022-12-21, 最終更新日: 2024-06-12)

• 主引用文献: Huber, S.,Braun, N.J.,Schmacke, L.C.,Murra, R.,Bender, D.,Hildt, E.,Heine, A.,Steinmetzer, T.; Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.; Arch Pharm, :e2400250-e2400250, 2024; PubMed: 38809037; DOI: 10.1002/ardp.202400250

実験手法

X-RAY DIFFRACTION (1.28 Å)