8APU

Crystal Structure of H. influenzae TrmD in complex with Compound 14

8APU の概要

• エントリーDOI: 10.2210/pdb8apu/pdb
• 分子名称: tRNA (guanine-N(1)-)-methyltransferase, 6-[[4-(aminomethyl)phenyl]methylamino]pyridine-3-carboxamide, CITRIC ACID, ... (4 entities in total)
• 機能のキーワード: methyltransferase, rna binding protein
• 由来する生物種: Haemophilus influenzae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30198.44

構造登録者

Hall, G.,Cowan, R.,Carr, M.D. (登録日: 2022-08-10, 公開日: 2023-06-14, 最終更新日: 2024-02-07)

• 主引用文献: Wilkinson, A.J.,Ooi, N.,Finlayson, J.,Lee, V.E.,Lyth, D.,Maskew, K.S.,Newman, R.,Orr, D.,Ansell, K.,Birchall, K.,Canning, P.,Coombs, P.,Fusani, L.,McIver, E.,Pisco, J.,Ireland, P.M.,Jenkins, C.,Norville, I.H.,Southern, S.J.,Cowan, R.,Hall, G.,Kettleborough, C.,Savage, V.J.,Cooper, I.R.; Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.; Bioorg.Med.Chem.Lett., 90:129331-129331, 2023; PubMed: 37187252; DOI: 10.1016/j.bmcl.2023.129331

実験手法

X-RAY DIFFRACTION (1.9 Å)