8AMC

Crystal Structure of cat allergen Fel d 4

Summary for 8AMC

• Entry DOI: 10.2210/pdb8amc/pdb
• Descriptor: Allergen Fel d 4, SULFATE ION (3 entities in total)
• Functional Keywords: lipocaline, cat allergene, lipocaline fold, allergen
• Biological source: Felis catus (domestic cat)
• Total number of polymer chains: 4
• Total formula weight: 89303.83

Authors

Schooltink, L.,Sagmeister, T.,Gottstein, N.,Pavkov-Keller, T.,Keller, W. (deposition date: 2022-08-03, release date: 2023-08-16, Last modification date: 2025-12-03)

Primary citation

Todorovic, N.,Trifonova, D.,Liu, Z.,Curin, M.,Schooltink, L.,Sagmeister, T.,Grininger, C.,Kiss, R.,Gottstein, N.,Gesslbauer, B.,Winkler, A.,Pavkov-Keller, T.,Karaulov, A.,Valenta, R.,Keller, W.
Major Cat Allergen Fel d 4: Structure and Identification of a Cross-Reactive IgE-Epitope-Containing Area.
Allergy, 2025

PubMed Abstract: Allergic sensitization to cats and other furry animals is a major cause of asthma and allergic rhinitis in more than 200 million people worldwide. According to the frequency of IgE recognition, allergen-specific IgE levels, and allergenic activity, Fel d 4 is a major allergen in the cat (Felis domesticus). The lipocalin allergen Fel d 4 is highly homologous to dog (Can f 6) and major horse (Equ c 1) allergens. Accordingly, IgE cross-reactivity to these allergens contributes to polysensitization and allergic responses upon exposure to different animals.

PubMed: 41286560
DOI: 10.1111/all.70146

Experimental method

X-RAY DIFFRACTION (2.95 Å)