8AM0
Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib)
Summary for 8AM0
Entry DOI | 10.2210/pdb8am0/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Isoform 3 of Phosphatidylinositol 3-kinase regulatory subunit alpha, (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, ... (7 entities in total) |
Functional Keywords | lipid kinase, phosphoinositide, 3-kinase, signaling, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 160453.96 |
Authors | Goncalves, M.,Johnson, J.L.,Roewer, K.M. (deposition date: 2022-08-02, release date: 2023-12-13, Last modification date: 2024-01-03) |
Primary citation | Lin, T.Y.,Ramsamooj, S.,Perrier, T.,Liberatore, K.,Lantier, L.,Vasan, N.,Karukurichi, K.,Hwang, S.K.,Kesicki, E.A.,Kastenhuber, E.R.,Wiederhold, T.,Yaron, T.M.,Huntsman, E.M.,Zhu, M.,Ma, Y.,Paddock, M.N.,Zhang, G.,Hopkins, B.D.,McGuinness, O.,Schwartz, R.E.,Ersoy, B.A.,Cantley, L.C.,Johnson, J.L.,Goncalves, M.D. Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep, 42:113535-113535, 2023 Cited by PubMed: 38060450DOI: 10.1016/j.celrep.2023.113535 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.818 Å) |
Structure validation
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