8AIC

X-ray structure of the receptor binding domain of Env glycoprotein of Simian Foamy virus

8AIC の概要

• エントリーDOI: 10.2210/pdb8aic/pdb
• 関連するPDBエントリー: 8AEZ
• 分子名称: Envelope glycoprotein gp130, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: receptor binding domain, viral protein
• 由来する生物種: Simian foamy virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88565.44

構造登録者

Backovic, M.,Fernandez, I. (登録日: 2022-07-26, 公開日: 2023-02-22, 最終更新日: 2024-11-13)

主引用文献

Fernandez, I.,Dynesen, L.T.,Coquin, Y.,Pederzoli, R.,Brun, D.,Haouz, A.,Gessain, A.,Rey, F.A.,Buseyne, F.,Backovic, M.
The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.
Nat Commun, 14:1262-1262, 2023

PubMed Abstract: The surface envelope glycoprotein (Env) of all retroviruses mediates virus binding to cells and fusion of the viral and cellular membranes. A structure-function relationship for the HIV Env that belongs to the Orthoretrovirus subfamily has been well established. Structural information is however largely missing for the Env of Foamy viruses (FVs), the second retroviral subfamily. In this work we present the X-ray structure of the receptor binding domain (RBD) of a simian FV Env at 2.57 Å resolution, revealing two subdomains and an unprecedented fold. We have generated a model for the organization of the RBDs within the trimeric Env, which indicates that the upper subdomains form a cage-like structure at the apex of the Env, and identified residues K342, R343, R359 and R369 in the lower subdomain as key players for the interaction of the RBD and viral particles with heparan sulfate.

PubMed: 36878926
DOI: 10.1038/s41467-023-36923-0

実験手法

X-RAY DIFFRACTION (2.8 Å)