8AHO

Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with cyanamide analogue 31

8AHO の概要

• エントリーDOI: 10.2210/pdb8aho/pdb
• 分子名称: Transpeptidase,Lipoprotein LppS, NITRATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: l, d-transpeptidase, ldtmt2, inhibitor, covalent, antimicrobial protein
• 由来する生物種: Mycobacterium tuberculosis; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76778.58

構造登録者

de Munnik, M.,Lang, P.A.,Brem, J.,Schofield, C.J. (登録日: 2022-07-22, 公開日: 2023-08-02)

• 主引用文献: de Munnik, M.,Lang, P.A.,De Dios Anton, F.,Cacho, M.,Bates, R.H.,Brem, J.,Rodriguez Miquel, B.,Schofield, C.J.; High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.; Chem Sci, 14:7262-7278, 2023; PubMed: 37416715; DOI: 10.1039/d2sc06858c

実験手法

X-RAY DIFFRACTION (2.3 Å)