8AHM

Crystal structure of tubulin in complex with C(13)/C(13')-Bis-Desmethyl-Disorazole Z

Summary for 8AHM

• Entry DOI: 10.2210/pdb8ahm/pdb
• Descriptor: Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (14 entities in total)
• Functional Keywords: tubulin, inhibitor, complex, cell cycle
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 270989.85

Authors

Oliva, M.A.,Diaz, J.F.,Altmann, K.H. (deposition date: 2022-07-22, release date: 2022-11-16, Last modification date: 2024-02-07)

• Primary citation: Bold, C.P.,Lucena-Agell, D.,Oliva, M.A.,Diaz, J.F.,Altmann, K.H.; Synthesis and Biological Evaluation of C(13)/C(13')-Bis(desmethyl)disorazole Z.; Angew.Chem.Int.Ed.Engl., 62:e202212190-e202212190, 2023; PubMed: 36281761; DOI: 10.1002/anie.202212190

Experimental method

X-RAY DIFFRACTION (2.42 Å)